BIOCHEMICAL RESPONSE OF NORMAL ALBINO RATS TO THE ADDITION OF AQUEOUS LEAVES EXTRACT OF HIBISCUS CANNABINUS AND MURRAYA KOENIGII IN RATS DRINKING WATER
Abstract
Experiments were conducted to determine thebiochemical effect of Hibiscus cannabinus and Murraya
koenigii extracts on normal albino rats using standard
methods. Analyses carried out indicated that the aqueous
leaf extract of H. cannabinus and M. koenigii exhibited
significant hypolipideamic activity in normal rats. Results
of phytochemical studies showed that flavonoids and
glycosides are the major chemical constituent of the leaf
extract. Overall results indicate a significant (P0.05)
reduction of serum cholesterol, triglycerol at both
concentration of 5 and 10 mg/Kg b.wt. No significant
effect is seen in the hematological indices, serum
glucose, Aspartate transaminase (AST) and Alanine
transaminase (ALT). The significance of this study is thus
discussed.