LIPID PROFILE OF ALLOXAN-INDUCED DIABETIC WISTAR RATS TREATED WITH METHANOLIC EXTRACT OF ADANSONIA DIGITATA FRUIT PULP

Abstract

This  study  was  carried  out  to  assess  the  antidiabetic  properties  of
Adansoniadigitata  fruit  pulp  by  evaluating  the  effect  of  its  methanolic
extract (MAD) on cholesterol, High Density Lipoprotein (HDL), Low Density
Lipoprotein  (LDL)  and  triglycerides.  Forty  eight  male  wistar/albino  rats
weighing 160 to 240 g were randomly distributed into six treatment groups
[Group1, Normal control, each given only 0.2 ml distilled water daily for 4
weeks; Group 2, diabetes control rats, induced with 150 mg/kg b.w., i.p.
administration  of  alloxan  and  thereafter  given  0.2  ml  distilled  water
throughout the  study period; Groups 3, 4 and 5, diabetic (i.p., 150 mg/kg
b.w. alloxan) rats were given single oral dose of MAD (100, 200 and 300
mg/kg  b.w.  respectively)  for   4  weeks;  Group  6,  diabetic  rats  (i.p.,  150
mg/kg b.w. alloxan) were treated with 84 mg/kg b.w. of Chloropropamide,
once daily for 4 weeks]. The serum concentration of cholesterol, HDL, LDL
and triglycerides of all the animals in each group were determined after the
14th  and  28th  treatment.  There  was  significant  (P<0.001)  reduction  of
serum cholesterol, LDL and Triglycerides when compared with the diabetic
control  rats.  These  reductions  were  dose  dependent  and  compared  well
with  values  obtained  in  the  standard  drug  control  group.   Significant
(P<0.001) increase in HDL were seen in the MAD experimental groups but
differed  significantly  (P<0.001)  with  reduction  seen  in  chloropropamide
group.