ANTI-INFLAMMATORY, ANALGESIC AND ANTI-PYRETIC EFFECTS OF ETHANOLIC AND AQUEOUS STEM BARK EXTRACTS OF BOSWELLIA DALZIELII H.

Abstract

This study evaluated the anti-inflammatory, analgesic and anti-pyretic activities of Boswellia dalzielii stem bark extracts, focusing on their potential as a natural alternative to conventional pain and inflammation treatments. The study involved the analgesic, antipyretic and anti-inflammatory impacts in albino rats. Antipyretic activity was assessed in pyrexia-induced rats, analgesic effects were evaluated using the hot plate test, and anti-inflammatory activity was measured through the rat paw edema model. The antipyretic assay revealed that, 300 mg/kg dose significantly reduced rectal temperature in pyrexia-induced rats, better than paracetamol. The analgesic activity of the extract was found to be dose-dependent, with 300 mg/kg showing significant and sustained analgesic effects compared to tramadol. The anti-inflammatory assessment revealed that the 300 mg/kg extract markedly inhibited edema formation, with effects to diclofenac. The results of this study showed that Boswellia dalzielii ethanol stem bark extract exhibited potent antipyretic, analgesic, and anti-inflammatory activities, with effects comparable to conventional medicine. Hence, suggests that it could serve as potent therapeutic agent for managing inflammation, pain and fever.