Preparation Of Bicyclic Lactones Using Lewis Acids Catalyzed Ene-Reaction

Authors

  • Makama B. Y. Department of Petroleum Chemistry, American University of Nigeria Lamido Zubairu Way, P.M.B. 2250 Yola, Adamawa State

Abstract

An efficient carbonyl ene-reaction procedure was developed for the preparation of 8-memebered cis-fused bicyclic lactones catalyzed by various Lewis acids at low temperatures. The optimum yield, temperature, catalyst concentration, solvent and reaction time were found to be 82%, -78 oC, MgBr.OEt2 1.3 equivalent, DCM and 3 hours respectively. A number of different Lewis Acids tested also gave good yields; 78%, -78 oC, BF3.OEt2, DCM, 24 hours; 74%, -78 oC, AlCl3, DCM, 48 hours

Author Biography

Makama B. Y., Department of Petroleum Chemistry, American University of Nigeria Lamido Zubairu Way, P.M.B. 2250 Yola, Adamawa State

Head and Senior Lecturer, Department of Biological Sciences

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Issue

Vol. 5 No. 2 (2010)

Section

ARTICLES